![]() In particular, we analyzed the type of TH supplementation, the route of administration, the dosages and duration of treatment and the outcomes chosen to evaluate the results. After a careful selection, we extracted data from four metanalyses, performed in different clinical conditions and diseases. Methods: We performed a review of the metanalyses focused on NTIS in critically ill patients. In this review, we analyze the reasons why TH treatment did not furnish convincing results regarding possible beneficial effects in reported IRCTs. Since many interventional randomized clinical trials (IRCT)s were not conclusive, current guidelines do not recommend treatment for these patients. Whether patients with NTIS should receive treatment with thyroid hormones (TH)s is still debated. ![]() 9Department Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Latina, Italyīackground and Objective: Nonthyroidal Illness Syndrome (NTIS) occurs in approximately 70% of patients admitted to Intensive Care Units (ICU)s and has been associated with increased risk of death.8Unit of Anesthesia, Intensive Care and Pain Medicine, Sant’Andrea University Hospital, Rome, Italy.7Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.6Health Management Director, Sant’Andrea University Hospital, Rome, Italy.5Department of Surgical and Medical Science and Translational Medicine, Sapienza University of Rome, Rome, Italy.4Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.3Unit of Medical Oncology, Sant’Andrea University Hospital, Rome, Italy.2Laboratory of Biomedical Research, Niccolò Cusano University Foundation, Rome, Italy.1Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.Salvatore Sciacchitano 1,2† Carlo Capalbo 3,4† Christian Napoli 5† Paolo Anibaldi 6 Valentina Salvati 7† Claudia De Vitis 1† Rita Mancini 1† Flaminia Coluzzi 8,9*† Monica Rocco 5,8†
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